
教育經歷:
2009.09 至2013.06,隴東學院,生物科學,學士
2014.09 至2016.06,蘭州大學,發(fā)育生物學,碩士
2016.09 至2021.06,蘭州大學,動物學,博士
工作經歷:
2021.09至2024.08,中國科學院廣州生物醫(yī)藥與健康研究院,博士后
2024.09至2024.12,中國科學院廣州生物醫(yī)藥與健康研究院,助理研究員
2025.01至今 中國科學院廣州生物醫(yī)藥與健康研究院,副研究員
專注于神經退行性疾病及神經系統(tǒng)損傷的再生醫(yī)學研究,主要通過基因編輯技術改造人源誘導多能干細胞(human iPSCs, hiPSCs),開發(fā)新型治療策略,應用于肌萎縮側索硬化癥(ALS)、帕金森?。?/span>PD)等神經退行性疾病,以及脊髓損傷和腦卒中等神經系統(tǒng)損傷的治療。
1.?國家自然科學基金-青年科學基金項目(2025.01-2027.12),項目負責人;
2.?中國博士后科學基金-特別資助項目(2023.06-2024.08),項目負責人;
3.?中國博士后科學基金-面上資助項目(2022.06-2023.08),項目負責人;
4.?中國科學院基礎研究項目-中國科學院廣州分院院長青年人才(培優(yōu))基金(2024.01-2024.12),項目負責人;
5.?廣州市科學技術局-基礎與應用基礎研究項目(2023.04-2025.03),項目負責人。
1.? Jiaowei Wang#,Wenguang Xie#,Nan Li#,Wenjuan Li#,Zhishuai Zhang#,Nana Fan,Zhen Ouyang,Yu Zhao,Chengdan Lai,Hao Li,Mengqi Chen,Longquan Quan,Yunpan Li,Yu Jiang,Wenqi Jia,Lixin Fu,Md Abdul Mazid,Yanling Zhu,Patrick H Maxwell,Guangjin Pan*,Miguel A Esteban*,Zhen Dai* and?Liangxue Lai*,?Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation,?Cell Stem Cell,2023,30(9):1235-1245.
2.? Ting Li *,Ting Xu,Jin Zhao,Hao Gao,Wenguang Xie, Depletion of iNOS-positive inflammatory cells decelerates neuronal degeneration and alleviates cerebral ischemic damage by suppressing the inflammatory response, Free Radical Biology and Medicine,2022,181(2022)209–220.
3.? Wenguang Xie#,Xiao-Ting Gong#,Xiaofeng Cheng#,Jingjing Cao*,Jin Zhao,Hao-Li Zhang*,and Shengxiang Zhang*, LIMPID: a versatile method for visualization of brain vascular networks, Biomaterials Science,2021,9: 2658-2669.
4.? Ting Li,Jin Zhao,Wenguang Xie,Wanru Yuan,Jing Guo,Shengru Pang,Wen-Biao Gan*,Diego Gómez-Nicola* and Shengxiang Zhang*,Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage, Journal of Neuroinflammation,2021,18(1):81.
5.? Xiao-Ting Gong#, Wenguang Xie#,Jing-Jing Cao*,Shengxiang Zhang*,Kanyi Pu* and Hao-Li Zhang *,NIR-emitting semiconducting polymer nanoparticles for in vivo two-photon vascular imaging, Biomaterials Science,2020,8: 2666-2672.
6. ?Na Zhang#,Dandan Chai#,Huifen Du,Kesheng Li*,Wenguang Xie,Xingwen Li,Rong Yang,Xiaowen Lian and Yang Xu,Expression of Reg IV and SOX9 and their correlation in human gastric cancer,BMC Cancer,2018,18:344.
7.? Zhijie Yang,Wenguang Xie,Furong Ju,Akbar khan,Shengxiang Zhang*,In vivo two-photon imaging reveals a role of progesterone in reducing axonal dieback after spinal cord injury in mice, Neuropharmacology,2016,116(116):30-37.

